The B-52 is an American strategic bomber aircraft.
B-52 or B52 may also refer to:
The B-52's, an American new wave band
The B-52's (album)
B52 (New York City bus), a bus line in Brooklyn, New York
B52 (chess opening), a chess opening based on the Sicilian Defence
B-52 (cocktail)
B-52 (hairstyle) or beehive, a hairstyle
B-52 Memorial Park, a park within the Orlando International Airport, Florida
Volvo B52 engine, a group of Volvo engines
Nora B-52, a Serbian self-propelled howitzer
HLA-B52, an HLA-B serotype
Bundesstraße 52, a federal highway in Germany
B52, route number for Kings Highway in Australia
B-52, a coded reference to Mao Zedong in Project 571
B-52, a pennant number of the Argentinian fast transport ship ARA Hércules (B-52)